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University of Pennsylvania Looking for Senior Research Investigator (Biomedical Sciences) Full Time
University Overview
The University of
Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This
historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12
highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s
distinctive interdisciplinary approach to scholarship and learning. As an employer Penn has been ranked nationally on many occasions with
the most recent award from Forbes who named Penn one of America’s Best Large Employers in 2023.
Penn offers a unique working
environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of
educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide
variety of atmospheres, Philadelphia is the perfect place to call home for work and play.
The University offers a competitive
benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a
wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and
resources, and much more.
Posted Job Title
Senior Research Investigator (Biomedical Sciences)
Job
Profile Title
Research Investigator, Senior
Job Description Summary
We are looking for a Senior Research
Investigator (SRI) under the direction of Dr. Ellen Pure, to assume the responsibility of decoding the cell-cell and cell-matrix
interactions in the tumor microenvironment of solid tumors including their impact on vulnerability to Immunotherapy, which is a rapidly
advancing modality for the treatment of many cancers. However, significant hurdles still remain, including complex multi-directional
heterotypic interactions between myriad populations in the tumor microenvironment, such as cancer-associated fibroblasts, tumor cells,
inflammatory and immune cells, cancer-associated endothelial cells and perciytes, as well as extracellular matrix that promote tumor
initiation, progression and metastasis.
This position is contingent upon funding.
Job Description
SRI will be
expected to carry translational studies of solid tumors, developing novel and utilizing state-of-the-art techniques to generate and test new
therapies and mechanisms of stromal-dependent tumorigenesis and therapeutic resistance. Requires >3 years experience in pre-clinical studies
of novel potential therapeutics (including multiple routes of drug delivery including intraveneous injection in mice) in xenograft,
syngeneic transplant and autochthonous tumor models as well as real-time 2-photon imaging of precision cut tumor slices. Skill in
quantification of tumor growth by ultrasound, bioluminescence image and caliper measurements is essential. Must have expertise in the
generation of human and mouse CAR T cells. Will collaborate with other Penn Investigators on the use of tumor-on-a-chip as orthoganol
approach to these technologies. Extensive experience in multi-parameter flow cytometry and multiplex immunofluorescence of tissue a use of
advanced digital imaging programs for quantitative analysis of the latter. Expertise in acquisition of second harmonic images and their
quantification is required. Generation and maintenance of novel compound mutant mouse colonies is required.
Job
Responsibilities
- Experimental design, conduct in vivo and in vitro studies, data acquisition, analysis and
interpretation - Conduct in vivo and in vitro studies and data acquisition
- Writing manuscripts, grant writing, preparation of
presentations, internal and external conference presentations - Supervise research specialist, undergraduate students, rotating
graduate students and junior postdocs - Other duties and responsibilities as assigned
This position is contingent upon
grant funding.
Qualifications
- Doctor of Medicine or Doctor of Philosophy, and 5 to 7 years of experience or
equivalent combination of education and experience is required. - General knowledge of cancer biology and cancer
immunology
Must have knowledge of:
- Pre-clinical cancer models
- Precision cut tumor slices
- Acquisition and
quantitative analysis of second harmonic imaging - Design of multiparameter flow cytometry panels; acquisition and analysis of
multiparameter flow cytometry data - Design of multiplex immunofluorescence tissue analysis
- Preparation of fibroblast derived
matrices and biochemical and functional analysis of FDMs - Tissue decellularization and proteomic and biologic analysis of tissue
matrix scaffolds - Generation of CART cells – viral transduces, mRNA electroporation, mRNA-LNP delivery in vitro and in situ analysis
Job Location – City, State
Philadelphia, Pennsylvania
Department / School
School of
Veterinary Medicine
Pay Range
$36,368.00 – $69,000.00 Annual Rate
Salary offers are made based on the candidate’s
qualifications, experience, skills, and education as they directly relate to the requirements of the position, as well as internal and
market factors and grade profile.
Affirmative Action Statement
Penn adheres to a policy that prohibits
discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin,
citizenship status, age, disability, veteran status, or any other legally protected class.
Special Requirements
Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the
requirements of the job.
University Benefits
- Health, Life, and Flexible Spending Accounts: Penn offers
comprehensive medical, prescription, behavioral health, dental, vision, and life insurance benefits to protect you and your family’s health
and welfare. You can also use flexible spending accounts to pay for eligible health care and dependent care expenses with pre-tax
dollars. - Tuition: Take advantage of Penn’s exceptional tuition benefits. You, your spouse, and your dependent children can
get tuition assistance here at Penn. Your dependent children are also eligible for tuition assistance at other
institutions. - Retirement: Penn offers generous retirement plans to help you save for your future. Penn’s Basic, Matching, and
Supplemental retirement plans allow you to save for retirement on a pre-tax or Roth basis. Choose from a wide variety of investment options
through TIAA and Vanguard. - Time Away from Work: Penn provides you with a substantial amount of time away from work during the
course of the year. This allows you to relax, take vacations, attend to personal affairs, recover from illness or injury, spend time with
family-whatever your personal needs may be. - Long-Term Care Insurance: In partnership with Genworth Financial, Penn offers
faculty and staff (and your eligible family members) long-term care insurance to help you cover some of the costs of long-term care services
received at home, in the community or in a nursing facility. If you apply when you’re newly hired, you won’t have to provide proof of good
health or be subject to underwriting requirements. Eligible family members must always provide proof of good health and are subject to
underwriting. - Wellness and Work-life Resources: Penn is committed to supporting our faculty and staff as they balance the
competing demands of work and personal life. That’s why we offer a wide variety of programs and resources to help you care for your health,
your family, and your work-life balance. - Professional and Personal Development: Penn provides an array of resources to help
you advance yourself personally and professionally. - University Resources: As a member of the Penn community, you have access
to a wide range of University resources as well as cultural and recreational activities. Take advantage of the University’s libraries and
athletic facilities, or visit our arboretum and art galleries. There’s always something going on at Penn, whether it’s a new exhibit at the
Penn Museum, the latest music or theater presentation at the Annenberg Center, or the Penn Relays at Franklin Field to name just a few
examples. As a member of the Penn community, you’re right in the middle of the excitement-and you and your family can enjoy many of these
activities for free. - Discounts and Special Services: From arts and entertainment to transportation and mortgages, you’ll find
great deals for University faculty and staff. Not only do Penn arts and cultural centers and museums offer free and discounted admission and
memberships to faculty and staff. You can also enjoy substantial savings on other goods and services such as new cars from Ford and General
Motors, cellular phone service plans, movie tickets, and admission to theme parks. - Flexible Work Hours: Flexible work options
offer creative approaches for completing work while promoting balance between work and personal commitments. These approaches involve use of
non-traditional work hours, locations, and/or job structures. - Penn Home Ownership Services: Penn offers a forgivable loan for
eligible employees interested in buying a home or currently residing in West Philadelphia, which can be used for closing costs or home
improvements. - Adoption Assistance: Penn will reimburse eligible employees on qualified expenses in connection with the legal
adoption of an eligible child, such as travel or court fees, for up to two adoptions in your household.
To learn more, please
visit: https://www.hr.upenn.edu/PennH
R/benefits-pay
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