JOB OPENING ID: 235079
REGULAR/TEMPORARY: Regular
ORGANIZATIONAL GROUP: Medical School
DEPARTMENT: MM Microbiology and Immunology
Responsibilities*
We are seeking a PhD level scientist with a minimum of 5 years of experience working with gnotobiotic animal models of inflammatory bowel disease. This scientist will work as part of a team to investigate a new model of inflammatory bowel disease (IBD) developed at the University of Michigan. This model uses interleukin-10 (IL-10) deficient mice to recreate a cytokine deficiency that occurs in humans (via loss of the IL-10 gene or the gene encoding IL-10 receptor), causing neonatal and pediatric IBD. Colonizing germfree IL-10-/- mice with a consortium of 14 different bacteria normally found in the colons of healthy humans results in IBD development, but only when mice are fed a low fiber diet that promotes mucosal erosion. We have also discovered a new bacterial metabolic pathway, isobutyrate production, that has the potential to decrease inflammation even in mice lacking IL-10 and fed a low fiber therapeutic diet (exclusive enteral nutrition, EEN) and have connected isobutyrate production to the presence of certain bacteria and certain EEN ingredients. Techniques that will be employed include, but are not limited to: analytical methods in mucosal immunology, RNA-sequencing, diet formulation and working with gnotobiotic mice, anaerobic microbiology, genomic and metagenomic sequencing and informatics analysis, ELISA and other general molecular biology methods. The successful candidate will be experienced in most of these methods.
Required Qualifications*
PhD level scientist with a minimum of 5 years of experience working with gnotobiotic animal models of inflammatory bowel disease.
Background Screening
Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.
Vaccine Requirements
COVID-19 vaccinations are required for all students, faculty and staff working in the following areas: Michigan Medicine including the Medical School, Dental School, University Health Service or the Mary A. Rackham Institute. This includes those working remotely and temporary workers. More information on this new policy is available on the U-M Health Response.
U-M EEO/AA Statement
The University of Michigan is an equal opportunity/affirmative action employer.
Job Detail
Job Opening ID
235079
Working Title
Research Investigator – Martens Lab
Job Title
RESEARCH INVESTIGATOR
Work Location
Ann Arbor Campus
Ann Arbor, MI
Full/Part Time
Full-Time
Regular/Temporary
Regular
FLSA Status
Exempt
Organizational Group
Medical School
Department
MM Microbiology and Immunology
Posting Begin/End Date
6/02/2023 – 6/09/2023
Career Interest
Primary
The University of Michigan is a non-discriminatory/affirmative action employer.
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