Novartis Hiring for Bioinformatician / Data Scientist, Sickle cell disease job in Cambridge Full Time

About the role
Location: Cambridge, MA

About this role:

Sickle cell disease (SCD) is the most common monogenic genetic disorder with ~300,000 babies born with the defect globally each year. It is an early onset debilitating multi-organ disease and leads to ~175,000 death per year, 70% of which occurs in Africa. In US, there are ~100,000 SCD patients and 1/13 African Americans carries one copy of the mutant SCD allele. The current standard of care is managing disease progression starting as early as infant. Gene therapy demonstrated its potential as one-time curative treatment in early clinical trials. Our goal is to make this paradigm-changing therapy accessible and affordable to all SCD patients.

The Discovery Sciences department in Novartis Biomedical Research is looking for a highly motivated NGS sequencing data analyst to join our quest.

This unique and prestigious position is sponsored by the Bill & Melinda Gates Foundation with current funding through December 2027.

You will work as part of a highly matrixed team consisting of hematologists, molecular and cell biologists, genome editing/engineering experts, sequencing technologies experts, data scientists, and other biomedical researchers.

Your Responsibilities Include:

* In-depth custom analysis of next-generation (Illumina, PacBio, etc.) sequencing data from targeted experiments.
Method development for quantification of gene editing outcomes (knock-ins, indels, etc.) in bulk cell populations.
* Identification and profiling of potential off-target effects at genome and transcriptome level.
* Interpretation of sequencing analysis in the broader project context and clear communication of results and experimental implications to the project team.
* Close collaboration with project team partners in the design of sequencing experiments for characterization of genome editing outcomes.
* Standardization and automation of analysis workflows, including development, maintenance, and clear documentation of analysis code base.Commitment to Diversity & Inclusion:
We are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please let us know the nature of your request, your contact information and the job requisition number in your message:

• Novartis: e-mail [email protected] or call +1 (877)395-2339
• Sandoz: e-mail [email protected] or call: +1-609-422-4098

Role Requirements
What you’ll bring to the role:

* Strong scientific background with a PhD degree in bioinformatics, computational biology, genetics and genomics, molecular biology, or related field, or an MS degree and 3+ years of relevant industry experience.
* If you are a current PhD graduate student, please list your anticipated graduation month on your resume
* Passion for in-depth analysis of biological data to achieve detailed interpretations of experimental outcomes.
* Demonstrated understanding of fundamental concepts in genetics/genomics, molecular and cellular biology, and bioinformatics.
* Experience with design of next-generation sequencing experiments and analysis of sequencing data to address scientific questions.
* Excellent data visualization, presentation, and communications skills.
* Knowledge of, or interest in learning genome editing biology and technology.
* Demonstrated knowledge of Python (preferred) or another high-level programming language and experience with version control.
* Scientific curiosity, interest in learning biology in a pharmaceutical setting, and a collaborative mentality.

Desirable Requirements:

* Experience with CRISPR/Cas9 gene editing or genome engineering.
* Familiarity with Bash or another Unix/Linux shell and high-performance computing environments.
* Hands-on experience with wet lab molecular genetics, molecular biology, and/or cell biology.

Why Novartis:

Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture

You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook: https://www.novartis.com/careers/benefits-rewards

Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams’ representative of the patients and communities we serve.

Novartis Compensation and Benefit Summary: The pay range for this position at commencement of employment is expected to be between $130,400 to $216,000/year; however, while salary ranges are effective from 1/1/23 through 12/31/23, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network