Novartis Hiring for Senior Scientist, Lentivirus Downstream Early Pipeline Development job in Boston Full Time

6000! This is the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on new technologies that have the potential to help produce therapeutic breakthroughs for patients. The Biologics Center (NBC) is accommodated within the Novartis Institutes for BioMedical Research (NIBR). NBC, in collaboration with the disease areas and technical expert groups, builds the future biologics therapy pipeline of Novartis through the discovery and creation of new antibody, protein, nucleic acid and virus-based molecules.

The Senior Scientist, Downstream Early Pipeline Development, supports lentivirus (LVV) gene therapy pipeline portfolio, developing a robust platform process for existing and novel LVV pseudotypes/cargo vectors, and building improved process technologies for LVV production. This role is also responsible for executing early-stage process development with the focus on developability of novel viral platforms.

What you’ll be doing: Your responsibilities include, but are not limited to:
• Perform small-scale purification process including ultracentrifugation, column chromatography, cell lysis, clarification, AKTA and TFF unit operations, and depth filtration for manufacturing of LVV gene therapy vectors across multiple preclinical programs and disease areas to ensure on time delivery.
• Work collaboratively with upstream process development and analytical development teams to develop a robust, scalable process for LVV production.
• Contribute to experimental design and execution for early development as well as innovative technology and platform evaluation for next generation capsids and cargo vectors.
• Assist knowledge transfer and work collaboratively with Technical Research & Development team to advance pipeline programs into clinical phases.
• Prepare protocols, reports and provide high quality data and electronic notebook documentation.
• Other related duties as assigned.

This position will be located at the Cambridge, MA site and will not have the ability to be located remotely. This position will require 0% travel as defined by the business (domestic and/ or international).What you’ll bring to the role:
• Bachelor’s degree in biochemistry, chemical engineering, bioengineering, or related technical field with 5+ years relevant experience or Master’s with 3 years of relevant experience, or PHD with 0+ years of relevant experience.
• Previous experience with a variety of biopharmaceutical purification processes such as chromatographic separation, depth filtration, tangential flow filtration, adventitious viral clearance, and impurity clearance.
• Demonstrated ability to work effectively in a cross-functional team.
• Individual team player who demonstrates technical proficiency and creativity, collaboration with others and independent thought. Ability to work in a matrix environment.
• Strong organization, analytical, and problem-solving skills with attention to details.

Desirable:
• Knowledge of viral gene therapy and previous experience with viral vector process development is preferred.

Why Novartis
766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what’s possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!
Imagine what you could do here at Novartis!

Commitment to Diversity & Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Accessibility and Reasonable Accommodations: The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to [email protected] call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

The pay range for this position at commencement of employment is expected to be between $92,800-139,200 a year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.