The Global Drug Development (GDD) organization oversees the development of new medicines discovered by our researchers and partners. We transform the lives of people by developing innovative and life-changing medicines.
We are looking for a motivated and independent lab-based Scientist (Expert) in our innovative Upstream Process Development group at San Diego, CA. In this position, you will be responsible to independently design, execute and analyze data from development studies to advance Adeno-associated virus (AAV) and Lentivirus (LVV) upstream process. You will also be the functional lead of pipeline programs and collaborate with colleagues from Downstream, Analytics, Preclinical and Manufacturing site to optimize, scale-up, and transfer processes for the clinical and commercial manufacturing of both new and licensed Novartis’ gene therapy products.
Your responsibilities will include, but are not limited to:
• Take the independent action to evaluate novel technologies to advance AAV and LVV upstream processes.
• Drive and initiate innovative solutions to solve specific scientific problems.
• Lead and support activities within the upstream unit to enhance AAV and LVV process productivity and quality and capture technology capability and performance.
• Write detailed experimental protocols, documents experimental studies according to established practices, review and present data at internal or external meetings representing upstream team.
• Collaborate closely with Downstream and Analytics colleagues to define Critical Quality attributes and assess the impact of upstream process parameters on quality.
• Participate in the design and execution of development studies to build upstream scale-down models.
• Supports active pre-clinical, clinical and commercial manufacturing through laboratory studies designed to illuminate fundamental process performance.
• Mentors junior colleagues while fostering a team environment committed to the principles of scientific excellence.What you’ll bring to the role:
• Bachelor’s biochemistry, chemical engineering, bioengineering, or related technical field with 4 years relevant experience or Master’s with 2 or PHD with 0.
• Extensive experience with production of virus or biologics from mammalian expression systems.
• Hands on experience with different cell lines (adherent and suspension), bioreactors, and scale-down model is required.
• Organized and systematic approach to viral or biologic production.
• Ability to multi-task and meet tight timelines is essential.
• Knowledge with a variety of biopharmaceutical purification processes such as chromatographic separation, depth filtration, precipitation and flocculation, tangential flow filtration, adventitious viral clearance, ultracentrifugation, and impurity clearance.
• Proficient in statistical analysis principles and approaches. Working knowledge and experience with Design of Experiment (DoE).
• Ability to analyze data to make date-driven decisions and further progress development strategies. Innovative with a continuous improvement mindset. Excellent team player with good communication skills.
The pay range for this position at commencement of employment is expected to be between $97,000 and $146,400/year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
Why Novartis?
236 million lives were touched by Novartis medicines in 2022, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.
We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.
We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what’s possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!
Imagine what you could do here at Novartis!
Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.
Accessibility and reasonable accommodations
The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to [email protected] call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
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