Merck & Co Hiring for Postdoctoral Research Fellow – Metabolic Disease Translational Models job in South San Francisco Full Time

Job Description

We are seeking an ideal candidate for our South San Francisco office! This candidate will be a highly innovative and talented Postdoctoral Research Fellow with experience in metabolic disease research and translational models to join our Quantitative Biosciences (Pharmacology) department. The successful candidate will be responsible for launching independent projects that leverage organotypic models to drive mechanistic understanding of disease pathogenesis and translational research, with a primary focus on non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver disease (NAFLD). She/he will work closely with a mentor to develop research plans, enable model development, conduct mechanistic studies, and generate novel insights for disease biology and therapeutic intervention. Our postdoctoral program aims to be the best-in-industry and is designed to provide an academic research focus in a commercial environment. With the resource, reach, and expertise of a global pharmaceutical company our postdoctoral researchers are positioned to excel in an institution committed to breakthrough innovation in research and discovery. If you are a highly motivated individual with a strong desire to pursue cutting edge translational research in metabolic diseases, we invite you to consider joining our team.

Key Responsibilities:

• Develop hypothesis driven project proposals and comprehensive study plans to conduct metabolic disease research using various translational models

• Establish and characterize organotypic models such as complex co-culture systems, 3D spheroids or organoids, and microphysiological system (MPS), using diverse methods and techniques
• Apply organotypic models for target discovery, pathway profiling, mechanistic investigation, and the evaluation of potential therapeutic strategies
• Ensure high-quality data generation, analysis, interpretation, and properly document all experimental design, protocols, and findings
• Maintain compliance with all laboratory trainings and safety requirements
• Evaluate and implement new enabling technologies and methods as needed
• Publish research findings in peer-reviewed journals, and present at scientific conferences and to internal teams

Required Education and Experience:

• Ph.D. in a relevant scientific discipline with less than 2 years of prior postdoctoral experience, or an expected Ph.D. degree with a 2023 calendar year graduation date

• Expertise in building and characterizing organotypic models for translational research such as primary cells or iPSCs, co-culture systems, 3D spheroids & organoids, or MPS

• Skilled in the development, execution, and interpretation of complex cellular assays
• Demonstrated ability to work independently and collaboratively to drive research initiatives and solve complex scientific/technical problems, with excellent organization and communication skills

Preferred Experience:

• Prior knowledge of a liver biology field (NASH, NAFLD, tissue regeneration, metabolism, etc.)
• Hands-on experience with high-content imaging methods and related data analysis software
• Background within the fields of metabolic disease, inflammation, or immunology
• Familiarity with molecular biology (i.e., cloning, qPCR, transfection, viral transduction, CRISPR, etc.) and general histology/immunostaining techniques
• Utilization of stable isotope tracers to interrogate metabolic flux via mass spectrometry

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We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.-

Who we are …

We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world’s most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us-and start making your impact today.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers’ Policy – Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Residents of Colorado

Click here to request this role’s pay range.

Under New York City, Colorado State, Washington State, and California State law, the Company is required to provide a reasonable estimate of the salary range for this job. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate’s relevant skills, experience, and education.

Expected salary range:

$75,000.00-$86,000.00

Available benefits include bonus eligibility, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. For Washington State Jobs, a summary of benefits is listed here.-

Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). -Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.

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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. -No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.-

Employee Status:
Regular

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Requisition ID:R242265