Be a part of the legacy: Postdoctoral Research Fellow Program
Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.
Project Title: Understanding and exploiting the capabilities of ultra-high throughput mass spectrometry (uHT-MS)
Position Overview: We are seeking a talented and motivated Postdoctoral Scientist passionate about the application of the latest analytical technologies within pharmaceutical drug discovery. Working within the DATA (Data Science, Automation, & Translational Analytics) organization in the Pharmacokinetics, Dynamics, Metabolism & Bioanalytics (PDMB) Department, you will be building a foundational understanding of Acoustic Ejection-Mass Spectrometry (AE-MS). AE-MS brings data acquisition times down by 10-100x or more compared with traditional discovery high throughput quantitative LC-MS/MS approaches opening up possibilities for redefining not just bioanalytical strategy but also how experiments are designed and executed. Based at our West Point, Pennsylvania facility, you will have access to a brand new state-of-the-art automated laboratory containing the latest AE-MS technologies coupled to automated platforms for development and execution of assay workflows. Taking the foundational knowledge you build; you will be working with cross-functional teams and as part of a research collaboration with the instrument vendor to define strategies for rapid AE-MS method development and applying this to the development of new workflows within Drug Metabolism and Pharmacokinetics (DMPK).
Responsibilities include but are not limited to:
Develop a strategy for rapid AE-MS method optimization and apply it to real-world bioanalytical applications in DMPK for an array of assay types.
Design and execution of experiments to build Structure Activity Relationship for mass spectrometry ionization efficiency. You will work with chemistry, automation and compound logistics, bioanalytic and data science teams.
Develop an understanding for application of AE-MS in real-time analysis of enzyme kinetic experiments.
Continue to build upon our company’s research collaboration with the instrument vendor.
Actively engage in the education and training of our company’s colleagues.
Write, publish and present (internally and externally) findings.
Education Minimum Requirement:–
Required Experience and Skills:–
Preferred Experience and Skills:
Resume keywords for recruiting team:
Mass spectrometry
Automation
Data processing
Data science
MRLpostdoc
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Employee Status:
Regular
Relocation:
VISA Sponsorship:
Travel Requirements:
Flexible Work Arrangements:
Not Applicable
Shift:
Valid Driving License:
Hazardous Material(s):
Requisition ID:R287742
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