GlaxoSmithKline Hiring for Investigator, Chemistry Drug Substance Development at Collegeville, PA  Full Time

GSK is seeking a proactive chemist to join Drug Substance Development at our US R&D Hub located in Upper Providence, PA. Our Drug Substance Development group supports the small molecule portfolio in GSK Pharma R&D with an inter-disciplinary team of process chemists, chemical engineers, materials scientists, and synthetic biochemists by developing the synthetic routes and associated manufacturing processes that turn those molecules into medicines. Through our network of 86 manufacturing sites, each year we produce nearly 4 billion packs of medicine, and we are committed to widening access to our products so that more people may benefit. A successful applicant will have an excellent practical and theoretical understanding of synthetic organic chemistry or a relevant technology and can design and execute high quality, thoughtful experimentation, while making significant contributions both independently and as a member of a team.

As a member of Drug Substance Development, you will use your chemistry knowledge and expertise to develop new chemistry routes for primary manufacture and contribute to the development and deployment of state-of-the-art processes and technologies to enable the delivery of our medicines. This is a highly practical role where you will be working in the R&D laboratories to generate new synthetic routes and process understanding that underpins the successful scale-up and commercial industrialization of GSK’s future manufacturing processes. Your focus will be to combine the information generated in laboratory studies with your strong knowledge of synthetic organic chemistry to develop sustainable pharmaceutical manufacturing routes and processes.

Why You

Success in GSK thrives on strong interpersonal skills and practical chemistry skills combined with a curious, inquisitive nature and a passion for science. You are equally passionate about developing yourself, developing new scientific methodologies, pushing the limits of innovation, and learning something new every day. You are an excellent team player, able to work with others either in the lab or in the office as well as within cross-functional teams. You are independent and able to plan and execute your own workload and deliver results. Your science is conducted with integrity, safety, and the highest standards. You pride yourself in your chemistry and enjoy science as much as we do.

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

• Design and perform experiments in a laboratory setting to meet project timelines and objectives.
• Think creatively to generate new ideas for new synthetic routes and simplifying process problems.
• Ensure that experimental work is communicated effectively at internal R&D meetings.
• Participate in technology transfer activities as appropriate to our manufacturing partners Pharma Supply Chain (PSC), other parts of R&D, and partner Contract Manufacturing Organizations (CMOs).
• Author or contributing to regulatory submissions, patents, scientific papers and other internal documentation relevant to the role.
• Comply with applicable Data Integrity, Quality, cGMP and regulatory requirements in all aspects of work.

Basic qualifications:

We are looking for professionals with these required skills to achieve our goals:

• Ph.D. in Chemistry or equivalent industrial experience with 1+ years expertise in synthetic organic chemistry

Preferred qualifications

If you have the following characteristics, it would be a plus:

• Experience in multistep synthesis of complex organic molecules
• Experience in High Throughput Experimentation for reaction optimization and process development activities
• Experience in Design of Experiments (DoE)
• Experience complex data processing and visualization using state-of-the-art platforms (i.e. Spotfire, JMP, etc).
• Experience in implementation of basic kinetic characterization of organic reactions
• Experience in one or more of the following areas: cheminformatics, computational chemistry, and machine-learning
• Experience in programming languages as applied to synthetic chemistry workflows (Python, etc.)
• Excellent problem-solving skills
• Experience in independent planning and execution of experiments
• Experience in independent interpretation of data from experiments and using it to make meaningful conclusions/decisions regarding the direction of future experimentation
• Scientific record demonstrating excellence in chemistry (e.g., publications, patents, or presentations)

Why GSK?

We’re combining the power of genetic and genomic insights into what causes disease, with the speed and scale of artificial intelligence and machine learning (AI/ML) to make better predictions about who a treatment might work for, and why. We believe this powerful combination of data and technology holds the key to fundamentally transforming medical discovery for the better, improving R&D success rates and shaping how even the most challenging diseases, like neurological conditions and cancer, can be both prevented and treated.

In 2021 we delivered four major product approvals: Cabenuva for HIV, Jemperli for endometrial cancer, Xevudy for COVID-19 and Apretude, our new long-acting medicine for HIV prevention.

Find out more:

#LI-GSK

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to positively impact the health of 2.5 billion people by the end of 2030.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We’re committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK’s commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit GSK’s Transparency Reporting site.